Jean Capulong Linsao
Department of Internal Medicine, Bulacan Medical Center
Title: A Rare Case of Eruptive Xanthoma in a Young Adult Male with Severe Hypertriglyceridemia, Hypercholesterolemia, and newly diagnosed Type 1 Diabetes
Biography
Biography: Jean Capulong Linsao
Abstract
Eruptive xanthomas are multiple, red-yellow papules that appear suddenly and are arranged in crops on the extensor surface of the extremities and the buttocks and are pathognomonic skin manifestations of severe hypertriglyceridemia, especially in patients with newly diagnosed or decompensated diabetes mellitus. In the Philippines, there are no nationwide prevalence or incidence studies on Type 1 Diabetes, particularly those in association with severe hypertriglyceridemia and eruptive xanthoma formation. We report the unusual case of a previously healthy young thin male adult, with no known comorbidities, and unremarkable family medical history, who initially manifested with generalized body weakness and weight loss, with initial laboratory work up showing severe hypercholesterolemia (825mg/dL) and hypertriglyceridemia (1000mg/dL), normoglycemia (97mg/dL). The serum was noted to be heavily lipemic and chylous. He was managed as Dyslipidemia. He eventually had polyphagia, polyuria, polydypsia, blurring of vision, further weight loss, appearance of eruptive xanthoma, associated with severe hyperglycemia (CBG at 500mg/dL), and was diagnosed and managed as Type 1 Diabetes. Through medical intervention with Insulin therapy and anti-dyslipidemic agents, there was marked resolution of symptoms, disappearance of eruptive xanthoma, and normalization of lipid levels. This case recognizes the importance of prompt awareness and recognition of eruptive xanthoma and its association with hypertriglyceridemia, hypercholesterolemia, newly diagnosed or decompensated diabetes mellitus to help prevent its serious complications with timely evaluation and therapy, and consequently decrease morbidity and mortality.